This study aimed to understand the response to COVID-19 in Nepal from January to August 2020 through review of mass media content and relevant policies published during the period. We identified three different news media as data source for the study based on their coverage, diversity of language, and access whereas 71 policy documents related to COVID-19 were identified for the study. The study centered around the responses, issues, and lessons with a focus on urban/city health system and urban population. We used qualitative method using framework analysis approach for the study. The major themes explored from the study were on governance, infrastructure development, capacity development and mobilization of the human resources, preparation of the health care system and impact of COVID-19.